Amaryl – Diabetes Medication


General Summary

  • Trade name: Amaryl
  • Generic name: Glimepiride
  • Drug class: Sulphonylureas
  • Manufacturer: Sanofi-Aventis

What is Amaryl?

Amaryl is an oral drug that lowers blood glucose levels and is used to treat type 2 diabetes. Glimepiride is the active ingredient involved which belongs to the sulphonylurea class of medicines, which works by increasing the secretion of natural insulin as well as the body’s insulin sensitivity.

Amaryl helps to reduce the amount of glucose in the blood by stimulating the release of insulin from the pancreas and encouraging cells to use glucose.

Usually, tablets are available in doses of 1mg, 2mg, 3mg and 4mg. A single daily dose of Amaryl is normally sufficient. It is recommended that a tablet is taken shortly before or during breakfast. If you skip breakfast, it should be taken during your first main meal. If you forget a dose, don’t take extra medicine to compensate. Instead, you should start your medication regimen again with your next meal.

Your GP will assign your dose and the frequency of your medication, depending on your blood glucose levels. These instructions will be included in the label that usually accompanies the medication.

Glimepiride tablets need to be stored in their original container and stored at room temperature.

Who Can Use Amaryl?

Adults with type 2 diabetes who can’t control their blood glucose levels through just diet and exercise can be treated with Amaryl. It can be taken on its own, or as a combination with metformin. Amaryl can also be used with insulin when it isn’t effective enough on its own.

Who Can’t Use Amaryl?

Amaryl shouldn’t be used by the following people:

  • Patients who are allergic or sensitive to or have ever had a reaction to any of the ingredients in the medicine.
  • Patients who are allergic or sensitive to or have ever had a reaction to sulphonylureas.
  • Patients who have type 1 diabetes.
  • Patients who are experiencingketoacidosis.
  • Patients who have kidney, liver or thyroid issues.
  • Women who are pregnant or breastfeeding.
  • Patients who are on dialysis.
  • Patients who have adrenal or pituitary gland problems.
  • Patients who have glucose-6-phosphate dehydrogenase deficiency.

Side Effects

There are some common, adverse side effects of Amaryl which includes:

  • Headache
  • Dizziness
  • Nausea
  • Skin rash and other allergic symptoms
  • Hypoglycaemia

There are also other side effects, however they occur very rarely:

  • Diarrhoea
  • Hypersensitivity reactions – breathing difficulties, lower blood pressure or shock.
  • Jaundice (yellowing of the skin and eyes)
  • Liver problems
  • Metabolic problems
  • Stomach pain and discomfort
  • Vomiting

This is not a complete list of side effects. A full list can usually be found in the patient information leaflet that is included with the medication.